41. What The Heck is Vasopressin?

What is vasopressin and how is it connected to Polycystic Kidney Disease? In this episode, the PKD Dietitian is going to:

  • Break down exactly what vasopressin is.
  • Explain how it functions in the body and how it affects your kidneys.
  • Highlight how it impacts PKD cyst growth.
  • PLUS share dietary and lifestyle factors that impact vasopressin levels...for better or worse.



BLOG: What is a Good Fluid Goal for Polycystic Kidney Disease?

EPISODE 3:  Listener Q - How Much Water Should I Drink?



  • Torres VE. Salt, water, and vasopressin in polycystic kidney disease. Kidney Int. 2020;98(4):831-834. doi:10.1016/j.kint.2020.06.001 ARTICLE LINK
  • Van Gastel MDA, Torres VE. Polycystic Kidney Disease and the Vasopressin Pathway. Ann Nutr Metab. 2017;70 Suppl 1:43-50. doi:10.1159/000463063 ARTICLE LINK
  • Taylor JM, Hamilton-Reeves JM, Sullivan DK, et al. Diet and polycystic kidney disease: A pilot intervention study. Clin Nutr. 2017;36(2):458-466. doi:10.1016/j.clnu.2016.01.003 ARTICLE LINK
  • Amro OW, Paulus JK, Noubary F, Perrone RD. Low-Osmolar Diet and Adjusted Water Intake for Vasopressin Reduction in Autosomal Dominant Polycystic Kidney Disease: A Pilot Randomized Controlled Trial. Am J Kidney Dis. 2016;68(6):882-891. doi:10.1053/j.ajkd.2016.07.023 ARTICLE LINK
  • Maatje D.A. van GastelVicente E. Torres; Polycystic Kidney Disease and the Vasopressin Pathway. Ann Nutr Metab 15 June 2017; 70 (Suppl. 1): 43–50. ARTICLE LINK
  • Torres, Vicente E.; Harris, Peter C. Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease. Journal of the American Society of Nephrology 25(1):p 18-32, January 2014. | DOI: 10.1681/ASN.2013040398 ARTICLE LINK
  • Wang, Xiaofang; Wu, Yanhong; Ward, Christopher J.; Harris, Peter C.; Torres, Vicente E.. Vasopressin Directly Regulates Cyst Growth in Polycystic Kidney Disease. Journal of the American Society of Nephrology 19(1):p 102-108, January 2008. | DOI: 10.1681/ASN.2007060688 ARTICLE LINK
  • Tasneem M, Mannix C, Wong A, Zhang J, Rangan G. Is serum copeptin a modifiable biomarker in autosomal dominant polycystic kidney disease?. World J Nephrol. 2018;7(2):51-57. doi:10.5527/wjn.v7.i2.51 ARTICLE LINK
  • Bankir L, Roussel R, Bouby N. Protein- and diabetes-induced glomerular hyperfiltration: role of glucagon, vasopressin, and urea. Am J Physiol Renal Physiol. 2015;309(1):F2-F23. doi:10.1152/ajprenal.00614.2014 ARTICLE LINK
  • Alwis US, Delanghe J, Dossche L, et al. Could Evening Dietary Protein Intake Play a Role in Nocturnal Polyuria?. J Clin Med. 2020;9(8):2532. Published 2020 Aug 5. doi:10.3390/jcm9082532 ARTICLE LINK
  • Grantham, Jared J.. Therapy for Polycystic Kidney Disease? It's Water, Stupid!. Journal of the American Society of Nephrology 19(1):p 1-7, January 2008. | DOI: 10.1681/ASN.2007101100 ARTICLE LINK
  • Yamada Y, Fujiki H, Mizuguchi H, et al. Nihon Yakurigaku Zasshi. 2022;157(4):254-260. doi:10.1254/fpj.22006 ARTICLE LINK
  • Rangan GK, Wong ATY, Munt A, et al. Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease. NEJM Evid. 2022;1(1):EVIDoa2100021. doi:10.1056/EVIDoa2100021 ARTICLE LINK
  • Sparapani S, Millet-Boureima C, Oliver J, et al. The Biology of Vasopressin. Biomedicines. 2021;9(1):89. Published 2021 Jan 18. doi:10.3390/biomedicines9010089 ARTICLE LINK



The PKD Dietitian Podcast is meant for educational purposes only.  Information presented should not be used in place of advice from a medical professional.